SAMe : SAH Gauge

The SAMe:SAH ratio is a better indicator of methylation potential than SAMe alone.

“The goal is not to methylate everything. The goal is to regulate the right genes, in the right tissues, at the right time, at the right intensity.”

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Simulation

Move SAMe, SAH and HCY to see how the ratio swings methylation potential.

64Healthy
SAMe
75
SAH
48
SAMe : SAH
1.57
Methylfolate (serum)15.8 ng/mL
Ref: 5–20 ng/mL
B12 (serum)780 pg/mL
Ref: 400–900 pg/mL
Choline / TMG (plasma)12.4 µmol/L
Ref: 7–20 µmol/L
Homocysteine (plasma)14.4 µmol/L
Ideal: <8 · High: >15
Oxidative stress (8-OHdG)6.7 ng/mg creat
Ref: 2–8 ng/mg creat
Think of SAMe as methylation 'fuel' and SAH as the 'exhaust' that builds up after use. Too much exhaust stalls the engine.