Methyl Donor Overload
More donors are not always better. The goal is balance, not saturation.
Simulation mode: receive a clinical case, adjust the variables and see your score.
Donor tank
0 / 100
5-MTHF0
Methyl-B120
SAMe0
TMG / Betaine0
Methionine0
Choline0
Patient sensitivity
Methyl stimulation0
Estimated tolerance100
Safer alternatives
- Hydroxo-B12 instead of methyl-B12
- Folinic acid instead of high-dose methylfolate
- Lower dose 5-MTHF (start 200 mcg)
- Magnesium / glycine for calming
- Riboflavin (B2) for MTHFR cofactor support
- Lifestyle first: sleep, glucose, stress
- Slow titration with symptom check-ins
What this means
More methyl is not always better. COMT slow patients may feel anxious, wired or sleepless. COMT fast patients may instead feel flat, unmotivated, crave sugar/caffeine, sleep poorly and gain belly fat — because too much methyl makes the body clear dopamine too fast and pushes the stress axis. Any new symptom after a supplement is information: reduce dose, switch form, and review with your clinician.
Disclaimer · This educational tool does not diagnose, treat or cure disease. Nutrients, supplements and lifestyle interventions should be personalized according to symptoms, lab results, medications, history and professional supervision.