Clinical Gene Group Cards

Genes grouped by function — desired regulatory pattern and what supports each group.

Group

DNA repair genes

MLH1MSH2MSH6PMS2BRCA1BRCA2ATMATRCHEK2PALB2RAD51ERCC1XPAXPCOGG1MUTYHMGMT
Ideal: Promoter / enhancer should generally remain accessible.

These genes are the DNA repair team — they correct mistakes, repair breaks and protect cells from accumulated damage.

Support: Folate · B12 · B2 · Magnesium · Zinc · Protein · NAC · Sulforaphane · Sleep · Lower toxins
Group

Tumor suppressor & cell-cycle genes

TP53CDKN2ARB1APCPTENVHLRASSF1ACDH1TIMP3DAPK1
Ideal: Promoter / enhancer should generally remain accessible.

These genes are the brakes of abnormal cell growth. If silenced, damaged cells may continue dividing.

Support: Stable glucose · Low inflammation · Exercise · Omega-3 · Curcumin · Vitamin D · Sleep · Weight control · Avoid smoking
Group

Antioxidant & detox genes

NFE2L2KEAP1SOD1SOD2SOD3CATGPX1GPX3GPX4GCLCGCLMGSRGSTP1GSTM1GSTT1NQO1HMOX1TXNRD1PRDX1ALDH2
Ideal: Responsive and available when needed.

These genes are the body's internal antioxidant and detox defense — they protect from oxidative stress, toxins and inflammation.

Support: Sulforaphane · NAC · Glycine · Selenium · Zinc · Vitamin C · CoQ10 · α-lipoic acid · Cruciferous vegetables · Reduced toxins
Group

Methylation & homocysteine genes

MTHFRMTRMTRRBHMTCBSSHMT1SHMT2MTHFD1DHFRTYMSPEMTCHDHDMGDHSLC19A1TCN2FUT2
Ideal: Functional and responsive.

These genes help the body produce and use methyl groups, recycle homocysteine, and support DNA synthesis, neurotransmitters and liver/brain health.

Support: 5-MTHF · B12 · B2 · B6 · TMG · Choline · Magnesium · Creatine · Protein · Leafy greens · Eggs
Group

Mitochondrial & energy genes

PPARGC1ASIRT1SIRT3PRKAA1PPARAUCP1UCP2TFAMFOXO3
Ideal: Responsive and metabolically flexible.

These genes help mitochondria produce energy, adapt to exercise, burn fat and reduce oxidative stress.

Support: Exercise · Zone 2 cardio · HIIT · Creatine · CoQ10 · Magnesium · B2 · Carnitine · PQQ · Sleep · Protein
Group

Inflammatory genes

IL6TNFIL1BNFKB1RELAPTGS2CRPNLRP3STAT3JAK2
Ideal: Responsive but not chronically overactive.

These genes help the body fight infection and injury. Chronic activation contributes to inflammation, pain, fatigue, insulin resistance and aging.

Support: Omega-3 · Curcumin · Vitamin D · Fiber · Probiotics · Sleep · Weight loss · Exercise · Mediterranean diet · Stress control
Group

Immune tolerance genes

IL10FOXP3TGFB1HLA-DRACTLA4PDCD1
Ideal: Balanced and responsive.

These genes help the immune system know when to calm down — important for tolerance and preventing excessive activation.

Support: Vitamin D · Omega-3 · Gut health · Fiber · Sleep · Stress reduction · Anti-inflammatory diet
Group

Metabolic & glucose genes

PPARGADIPOQLEPLEPRINSRIRS1SLC2A4TCF7L2FTOMC4R
Ideal: Responsive and balanced.

These genes help control insulin, glucose, fat storage, appetite and metabolic flexibility.

Support: Resistance training · Walks after meals · Protein breakfast · Berberine · Myo-inositol · Magnesium · Fiber · Weight reduction · Stable sleep
Group

Repetitive DNA / retroelements

LINE-1AluHERV-KHERV-W
Ideal: More methylated / controlled.

Repetitive or ancient viral-like sequences. They usually need to stay controlled to reduce genomic noise and instability.

Support: Folate · B12 · B2 · B6 · Choline · TMG · Protein · Avoid smoking · Reduce toxins · Control inflammation · Sleep