Methylation is not one thing
Three distinct layers: genetic capacity, epigenetic pattern, and current clinical picture.
“The goal is not to methylate everything. The goal is to regulate the right genes, in the right tissues, at the right time, at the right intensity.”
🧬
Genetic methylation capacity
Your genotype (MTHFR, MTR, MTRR, BHMT, COMT…) sets the upper limit of how efficiently your enzymes can move methyl groups.
🔁
Epigenetic methylation patterns
The actual methyl marks sitting on your DNA right now — shaped by environment, nutrition, stress, sleep, age and exposures over a lifetime.
🩺
Clinical methylation status
What labs and symptoms suggest right now: homocysteine, MMA, SAMe/SAH, B12 forms, folate status, oxidative stress, mood and energy.
Genetics ≠ epigenetics ≠ clinical status. A patient with 'bad MTHFR' may have excellent clinical methylation — and vice versa.