Histones vs DNA

DNA methylation doesn't act alone. Histone marks around the gene decide whether chromatin opens or closes.

“The goal is not to methylate everything. The goal is to regulate the right genes, in the right tissues, at the right time, at the right intensity.”

nucleosomenucleosomenucleosomenucleosomeOpen chromatin — gene ACTIVEExpression: 100%
Marks present
Think of DNA as a book and histones as page folds. Some folds open a chapter, others close it — DNA methylation is only one of the tools.