Methylation Fuel Simulator

Enter the patient's HCY, mark gene variants, toggle CBS mode — watch the pathway respond live.

“The goal is not to methylate everything. The goal is to regulate the right genes, in the right tissues, at the right time, at the right intensity.”

Homocysteine — blood value
µmol/L
Optimal HCY
Methylation and clearance appear balanced.
Methylation Capacity
100/100
Excellent balance
HCY Clearance
100/100
Good clearance
Glutathione Defense
58/100
Fragile
FolateFolic Acid5-MTHFMTRMethionineSAMeMethylationSAHHCYBHMTCBSGlutathione
HCY lab: 8Predicted HCY: 8.0 µmol/LFlow: 58%
Folate400 mcg DFE
Folic Acid (synthetic)200 mcg
5-MTHF / L-Methylfolate400 mcg
Vitamin B12500 mcg
Vitamin B6 / P5P25 mg
Riboflavin B225 mg
Choline500 mg
Betaine / TMG1000 mg
Magnesium350 mg
Zinc15 mg
Selenium150 mcg
Methionine1000 mg
SAMe400 mg
500 mg
Oxidative stress30%
Genes & variants (click to cycle)
normal het hom
Folate entry & one-carbon
Main methylation
BHMT backup
Methionine / SAMe
Transsulfuration / GSH
What this means
HCY of 8 µmol/L (optimal hcy). No significant bottlenecks in the current pattern. Maintain adequate cofactors and monitor with periodic labs.
The goal is not to methylate everything. It is to keep balanced flow between folate, B12, methionine, SAMe, SAH, homocysteine, BHMT, CBS and glutathione. A normal HCY is important but does not show the whole cycle. Real balance depends on genetics, cofactors, labs, oxidative stress, renal/thyroid function, diet, medications and clinical context.
Current pattern in good balance.
This simulator is educational. It does not diagnose or treat disease. Homocysteine interpretation and supplement use should be confirmed with a qualified healthcare professional, especially in pregnancy, kidney disease, cancer, neurological symptoms, anticoagulant/anticonvulsant/methotrexate/levodopa/antidepressant use, or suspected B12 deficiency.
See where the methyl group lands
The SAMe produced here becomes the CH₃ deposited on DNA. Open the 3D DNA Simulator.