One-carbon metabolism map

Tap any node to understand its role in methylation.

The goal is not to methylate everything. The goal is to regulate the right genes, in the right tissues, at the right time, at the right intensity.

DHFRDHFRSHMT (B6)MTHFR (B2)MTR (B12)MATMTasesAHCYBHMT (TMG)CBS (B6)GCL · GSSFolateDHFTHF5,10-MTHF5-MTHFMethionineSAMeSAHHomocysteineCysteineGlutathioneFolate cycleMethionine cycleTranssulfuration
Methionine cycle

SAMe

S-adenosylmethionine — the universal methyl donor.

This pathway depends on several B vitamins working together.